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Where in the cell is the GEF for Ran GTPase localized? What is its role in...

Where in the cell is the GEF for Ran GTPase localized? What is its role in the transport of proteins?

What do mitochondrial and ER signal peptidases have in common?

How do they differ? (Think about their location within the organelle.)

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Ans) GEFs or Guanine nucleotide exchange factors are proteins present in the cell which helps in activating the GTPase and this is done by stimulating the release of GDP which helps in association of the GTP. The location of the GEFs helps in determining where the GTPase will be active inside a cell. The Ran GEF is present or localized inside the nucleus and it helps in converting the RanGDP to RanGTP inside the nucleus. The conversion helps in the activation of the Ran which aids in the export of the proteins.

The GEFs helps in releasing the GDP and binding of the GTP in the process of transport of proteins. The GEFs are basically factors which are associated with the activation of the small GTPase and they help in the process of intracellular signaling. The GEF Ran GTPase helps in converting the RanGDP to RanGTP in the nucleus and helps in activation of the Ran protein which helps in exporting proteins out of the nucleus.

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