Question

Why is it important that [transcription factor] – [DNA] interactions are based on noncovalent bonds?

  1. Why is it important that [transcription factor] – [DNA] interactions are based on noncovalent bonds?
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Answer #1

The interactions between the DNA and transcription factors are non-covalent and specific so that they can perform necessary functions which is meant to be. At the same time, once the necessary functions gets over, the interactions that are merely non-covalent gets degraded so that the molecules [DNA and transcription factors] can provide additional functions that are necessary for the cell. The interactions between the DNA and proteins are transient, hence need to be non-covalent [requires less energy to break] and at the same time non-specific. Cell has evolved in such a way that, it carries out functions in the cell at minimal expense of energy.

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