Question 1Coupled Reactions: (a) Calculate Keq for the metabolically unfavourable reaction A → B, for which...
Question 1Coupled Reactions:
(a) Calculate Keq for the metabolically unfavourable reaction A → B, for which DGo’=25 kJ mol-1
(b) Using DGo ’ = -32.2 kJ mol-1 for the hydrolysis of ATP, calculate Keq for the coupled reaction A + ATP + H2O → B + ADP + Pi (Hint: consider the two half reactions separately)
(c) Assuming the ratio of ATP:[ADP x Pi] is 10-4 , calculate the ratio of A:B in the coupled reaction.
(d) How do the values for Keq and A:B ratio compare between the coupled and uncoupled reactions?
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Question 1Coupled Reactions:
(a) Calculate Keq for the metabolically unfavourable reaction A
→ B, for which...
the enzyme hexokinase can catalyze the following reaction: fructose + ATP -> fructose 6 phosphate +...
the enzyme hexokinase can catalyze the following
reaction:
fructose + ATP -> fructose 6 phosphate + adp
if the deltaG of hydrolysis of fructose 6 phosphate to
fructose + Pi is -13.8 kj/mol and hydrolysis of atp to adp + pi is
-30kj/mol, calculate Keq for the reaction above (R = 8.31 j mol-1
K-1, T = 298 k
3a. The enzyme hexokinase can catalyze the following reaction: Fructose + ATP → Fructose-6-phosphate + ADP If the ΔGo of hydrolysis...
Considering the energy changes associated with the individual reactions below, which reaction can be coupled with...
Considering the energy changes associated with the individual reactions below, which reaction can be coupled with the hydrolysis of ATP to generate a coupled reaction that is energetically favorable? Energy. change -7.3 kcal/mol ATP + H20 → ADP + HPO42- succinyl CoA + H20 → succinate + HSCOA + -9.4 HPO42- fructose 1,6-bisphosphate + H20 → fructose 6- kcal/mol -3.9 kcal/mol phosphate + HPO42- 1,3-bisphosphoglycerate + H2O → 3- phosphoglycerate + HPO42- -11.8 kcal/mol A) Succinate + HSCOA + HPO42-→...
2. For the following reaction: ATP+ creatine + H2O creatine phosphate + ADP + P, The...
2. For the following reaction: ATP+ creatine + H2O creatine phosphate + ADP + P, The relevant half reactions are: ATP → ADP + Pi Creatine phosphate + H2O-> creatine AG-30.5 kJ/mol ΔG°,--43.1 kJ/mol a. (2 pts.) Calculate the ΔG°, for the overall reaction. b. (2 pts.) Is the reaction spontaneous or non-spontaneous? Endergonic or exergonic?
A critical reaction in the production of energy to do work or drive chemical reactions in...
A critical reaction in the production of energy to do work or
drive chemical reactions in biological systems is the hydrolysis of
adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as
described by the reaction.....
Thank you!!!
A critical reaction in the production of energy to do work or drive chemical reactions in biological systems is the hydrolysis of adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as described by the reaction ATP(aq) + H2O(1) ADP(aq) + HPO2 (aq) in a biological...
A critical reaction in the production of energy to do work or drive chemical reactions in...
A critical reaction in the production of energy to do work or
drive chemical reactions in biological systems is the hydrolysis of
adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as
described by
ATP(aq)+ H2O(l)
ADP(aq) + H2PO4(aq)
for which ΔG°rxn = –30.5 kJ/mol at 37.0 °C and pH 7.0. Calculate
the value of ΔGrxn in a biological cell in which [ATP] = 5.0 mM,
[ADP] = 0.80 mM, and [HPO42–] = 5.0 mM.
Grxn
= ___ KJ/mol
Is the hydrolysis...
5.The following reaction has a ΔG°'--61.9 kJ/mol at 25°C, Phosphoenolpyruvate (PEP) +H2O Pyruvate + Inorganic Phosphate...
5.The following reaction has a ΔG°'--61.9 kJ/mol at 25°C, Phosphoenolpyruvate (PEP) +H2O Pyruvate + Inorganic Phosphate (Pi) (a) Is the reaction favorable under standard biochemical conditions? Explain your answer. (b) What is the equilibrium constant (K) of this reaction at 25°C? In cells the direct hydrolysis of PEP rarely occurs. Rather, the hydrolysis of PEP and the reverse hydrolysis of ATP are coupled (c) w rite out the coupled reaction and determine its ΔG at 25°C The hydrolysis of ATP...
A critical reaction in the production of energy to do work or drive chemical reactions in...
A critical reaction in the production of energy to do work or drive chemical reactions in biological systems is the hydrolysis of adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as described by the reaction ATP(aq) + H2O(l) —— ADP(aq) + HPO2 (aq) for which AGix = -30.5 kJ/mol at 37.0 °C and pH 7.0. Calculate the value of AGrxn in a biological cell in which [ATP] = 5.0 mm, (ADP) = 0.20 mM, and [HPO2-) = 5.0 mM. AGxn= kJ/mol...
We have seen all term that cells use the hydrolysis of high energy phosphate from ATP...
We have seen all term that cells use the hydrolysis of high energy phosphate from ATP to make metabolic reactions thermodynamically favorable. Whereas most enzymes that utilize ATP hydrolyze between the b and g phosphates (yielding ADP + Pi), some enzymes hydrolyze ATP between the a and b phosphates (yielding AMP and PPi). ∆G°’ of phosphate hydrolysis is -31 kJ/mol for ATP + H2O --> ADP + Pi, and ∆G°’ of phosphate hydrolysis is -46.5 kJ/mol for ATP + H2O...
In the first step of glycolysis, the given two reactions are coupled. reaction 1: reaction 2:...
In the first step of glycolysis, the given two reactions are coupled. reaction 1: reaction 2: glucose +P: ATP + H2O glucose-6-phosphate + H,O + ADP + P AG = +13.8 kJ/mol AG = -30.5 kJ/mol Answer the four questions about the first step of glycolysis. Is reaction 2 spontaneous or nonspontaneous? O nonspontaneous O spontaneous Complete the net chemical equation. ATP+ + Calculate the overall AG for the coupled reaction. AG = kJ/mol Is the first step in glycolysis...
A critical reaction in the production of energy to do work or drive chemical reactions in...
A critical reaction in the production of energy to do work or drive chemical reactions in biological systems is the hydrolysis of adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as described by the reaction ATP(aq) + H2O(1) ADP(aq) + HPO- (aq) - for which AG x = -30.5 kJ/mol at 37.0 °C and pH 7.0. Calculate the value of AG in a biological cell in which (ATP) = 5.0 mm, (ADP) = 0.90 mm, and [HPO-) = 5.0 mM. AG...
the enzyme hexokinase can catalyze the following
reaction:
fructose + ATP -> fructose 6 phosphate + adp
if the deltaG of hydrolysis of fructose 6 phosphate to
fructose + Pi is -13.8 kj/mol and hydrolysis of atp to adp + pi is
-30kj/mol, calculate Keq for the reaction above (R = 8.31 j mol-1
K-1, T = 298 k
3a. The enzyme hexokinase can catalyze the following reaction: Fructose + ATP → Fructose-6-phosphate + ADP If the ΔGo of hydrolysis...
Considering the energy changes associated with the individual reactions below, which reaction can be coupled with the hydrolysis of ATP to generate a coupled reaction that is energetically favorable? Energy. change -7.3 kcal/mol ATP + H20 → ADP + HPO42- succinyl CoA + H20 → succinate + HSCOA + -9.4 HPO42- fructose 1,6-bisphosphate + H20 → fructose 6- kcal/mol -3.9 kcal/mol phosphate + HPO42- 1,3-bisphosphoglycerate + H2O → 3- phosphoglycerate + HPO42- -11.8 kcal/mol A) Succinate + HSCOA + HPO42-→...
2. For the following reaction: ATP+ creatine + H2O creatine phosphate + ADP + P, The relevant half reactions are: ATP → ADP + Pi Creatine phosphate + H2O-> creatine AG-30.5 kJ/mol ΔG°,--43.1 kJ/mol a. (2 pts.) Calculate the ΔG°, for the overall reaction. b. (2 pts.) Is the reaction spontaneous or non-spontaneous? Endergonic or exergonic?
A critical reaction in the production of energy to do work or
drive chemical reactions in biological systems is the hydrolysis of
adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as
described by the reaction.....
Thank you!!!
A critical reaction in the production of energy to do work or drive chemical reactions in biological systems is the hydrolysis of adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as described by the reaction ATP(aq) + H2O(1) ADP(aq) + HPO2 (aq) in a biological...
A critical reaction in the production of energy to do work or
drive chemical reactions in biological systems is the hydrolysis of
adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as
described by
ATP(aq)+ H2O(l)
ADP(aq) + H2PO4(aq)
for which ΔG°rxn = –30.5 kJ/mol at 37.0 °C and pH 7.0. Calculate
the value of ΔGrxn in a biological cell in which [ATP] = 5.0 mM,
[ADP] = 0.80 mM, and [HPO42–] = 5.0 mM.
Grxn
= ___ KJ/mol
Is the hydrolysis...
5.The following reaction has a ΔG°'--61.9 kJ/mol at 25°C, Phosphoenolpyruvate (PEP) +H2O Pyruvate + Inorganic Phosphate (Pi) (a) Is the reaction favorable under standard biochemical conditions? Explain your answer. (b) What is the equilibrium constant (K) of this reaction at 25°C? In cells the direct hydrolysis of PEP rarely occurs. Rather, the hydrolysis of PEP and the reverse hydrolysis of ATP are coupled (c) w rite out the coupled reaction and determine its ΔG at 25°C The hydrolysis of ATP...
A critical reaction in the production of energy to do work or drive chemical reactions in biological systems is the hydrolysis of adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as described by the reaction ATP(aq) + H2O(l) —— ADP(aq) + HPO2 (aq) for which AGix = -30.5 kJ/mol at 37.0 °C and pH 7.0. Calculate the value of AGrxn in a biological cell in which [ATP] = 5.0 mm, (ADP) = 0.20 mM, and [HPO2-) = 5.0 mM. AGxn= kJ/mol...
In the first step of glycolysis, the given two reactions are coupled. reaction 1: reaction 2: glucose +P: ATP + H2O glucose-6-phosphate + H,O + ADP + P AG = +13.8 kJ/mol AG = -30.5 kJ/mol Answer the four questions about the first step of glycolysis. Is reaction 2 spontaneous or nonspontaneous? O nonspontaneous O spontaneous Complete the net chemical equation. ATP+ + Calculate the overall AG for the coupled reaction. AG = kJ/mol Is the first step in glycolysis...
A critical reaction in the production of energy to do work or drive chemical reactions in biological systems is the hydrolysis of adenosine triphosphate, ATP, to adenosine diphosphate, ADP, as described by the reaction ATP(aq) + H2O(1) ADP(aq) + HPO- (aq) - for which AG x = -30.5 kJ/mol at 37.0 °C and pH 7.0. Calculate the value of AG in a biological cell in which (ATP) = 5.0 mm, (ADP) = 0.90 mm, and [HPO-) = 5.0 mM. AG...
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