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4) In the event that a patient presents with markers for more than one drug target,...

4) In the event that a patient presents with markers for more than one drug target, combination drug therapy can result in much improved patient outcomes. Would you recommend a combination of drugs to be used for treatment of either patient? If so what combination of drugs would you recommend and for which patient?

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Combined therapy of a ovarian cancer has a long history. The first drug which was combined with other chemotheraupatics was CISPLATIN. It turned to be effective given together with alkylating agents as well as taxanes. These type of combination of drugs would be recommended to ovarian cancer patients....

There are many advantages of using drug combination---

  • The possible increase of efficacy of the therapeutic effect, especially when drugs in sequence differ in their mechanism of action, but give similar effects.
  • Using drug regimens allows decreasing dosages oc each component thus their toxicity, which result in less severe adverse effects of each.
  • It minimizing the development of drug resistance, which is a big challenge for modern medicine and very often is the most important limitation and a problem difficult to avoid especially in cancer and bacterial infection treatment.
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