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DNA to Protein Describe the mutation that created the HbS allele: type of mutation, location of...

DNA to Protein

  • Describe the mutation that created the HbS allele: type of mutation, location of mutation on HbA sequence (# of bases from beginning of sequence), nucleotide change (from which base to which base?).
  • Describe the effect of this mutation on amino acid sequence of beta-globin polypeptide chain: effect of mutation on codon, which amino acid was changed (# amino acids from beginning of chain), what was the amino acid change (from which amino acid to which amino acid?)
  • Describe the effect of amino acid change on protein function: How does HbS function differently than HbA in RBC?
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Answer #1

The missence mutation creat the Hbs allele which responsible for sickle cell anemia in human.CTOCINE THYMINE CYTOCINE (CTC)codon of DNA and Guanine Adenine Guanine (GAG) of mRNA are responsible for the Glutamic acid which make the normal Hb .But due to the mutation the Thymine in DNA is changed to Adenine which facillate the production of Valine , a amino acid creares the Hbs or sickle cell haemoglobin.

Normal haemoglpbin in RBC carry oxygen through small vesicle but due to Hbs gene the haemoglobin became crescent shape which cannt enter the small blood vessel as a result cell get damage.

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