You would like to develop an immunosuppressive. You decide to make an inhibitor of Lck kinase....
You would like to develop an immunosuppressive. You decide to make an inhibitor of Lck kinase. Why would it make you more likely to be susceptible to bacterial infections?
Homework Answers
SOLUTION
Lck also known as lymphocyte-specific protein tyrosine kinase is found in the specialised cells of immune system called as lymphocytes
- It is commonly found in Tcells and is associated with the cytoplasmic tailing of CD4 and CD8 co-receptors on T-helper cells and cytotoxic T cells to assist signalling from T cell receptor complex
- It plays an essential role in selection and maturation of developing T cells in the thymus and in the function of mature T cells
- It also plays a key role in T-cell antigen receptor linked signal transduction pathways
These statements prove that lck kinase play a crucial role in maintaining the immune status of the body so if we plan to develop an immunosuppressive and decide to make an inhibitor of Lck kinase , it will make the person more susceptibe to bacterial infections
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