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Steroid hormones usually result in a longer-term effect on cellular function, explain why this is the...

Steroid hormones usually result in a longer-term effect on cellular function, explain why this is the case.

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  • Long-term effects usually involve interaction of the hormone with a specific intracellular steroid-binding protein called a receptor.
  • These receptors are DNA-binding proteins of the steroid/thyroid hormone receptor superfamily.
  • The steroid-receptor complex binds to hormone-responsive elements on the chromatin and regulates gene transcription.
  • Steroid receptor genes are only expressed in target tissues, where their presence determines accumulation of the hormone in the cell nucleus and facilitates steroid entry into the target cell by the law of mass action.
  • This mode of cellular action is generally referred to as a genomic action.
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