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Signaling of GPCRs (G-protein coupled receptors) is terminated by which mechanism? Phosphorylation of receptors by cAMP...

Signaling of GPCRs (G-protein coupled receptors) is terminated by which mechanism?

Phosphorylation of receptors by cAMP (cyclic adenosine monophosphate) activated PKA (protein kinase A), which blocks the interaction with G-protein
Cleavage of the GPCRs by receptor-specific serine or threonine proteases
Hydrolysis of GTP (guanosine triphosphate) to GDP (guonosine diphosphate) by G-protein α.
None of the above
All of the above

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Answer #1

G protein- coupled receptor(GPCR) constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and cellular responses. While coupling with G protein they pass through the cell membrane seven times and thus, they are also known as seven transmembrane receptors.

Signaling of GPCRs is terminated by

1. Phospohorylation of receptors by cAMP activated PKA, which blocks the interaction with G- protein.

2. Hydrolysis of GTP to GDP by G-protein alpha.

Cleavage of GPCRs by receptor specific serine or threonine proteases regulates signal transduction and this mechanism is not involved in the termination process.

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