Question

A) Extraction - when performing liquid - liquid extraction with a combination of an acidified aqueous phase and an organic solvent; what phase would a basic compound (e.g., an amine; R-NH 2) prefer amongst the options below:

1- the basic compound will be ionised and prefer the organic phase

2- the basic compound will be nautral and end up in the organic phase

3- the basic compound will be ionised and prefer the acidic aqueous phase

B) Extraction - when you perform liquid - liquid extraction with a combination of a basic aqueous phase and an organic solvent; what stage would an acidic compound (e.g., a carboxylic acid; R-COOH) prefer amongst the alternatives below?

1- the acidic compound will be ionized and prefer the organic phase.

2- the acidic compound will be nautral and end up in the organic phase.

3- the acidic compound will be ionized and prefer the basic aquoeus phase.

Answer 1

Correct option for A) is : "3- the basic compound will be ionised and prefer the acidic aqueous phase."

Amine group become protonated in presence of acid and become ionic. Protonated amine is now become polar and dissolve in polar acidic aqueous phase.

Correct option for B) is : "3- the acidic compound will be ionized and prefer the basic aquoeus phase."

Carboxylic group get deprotonated in presence of base and become ionic. Deprotonated carboxylic acid is now polar and dissolve in polar basic aqueous phase.

I hope remember the concept of "like dissolve like " concept.

Aqueous phase are polar and organic solvent are non- polar.

Hence, both protonated amine(polar) and deprotonated carboxylic acid (polar) dissolve in aqueous phase(polar).

I hope you understand it well.