Question

What is the protein target for albendazole for anti cancer computational studies
. Tell with a paper refrence

Answer 1

Albendazole (ABZ) is an anti parasite compound capable of imparing microtubule formation. ABZ could be repurposed as a potential anti angiogenic drug to its potent inhibition of vascular endothelial growth factor in ovarian cancer with ascites.

Cancer is a major public health problem these days in many parts of the world .Standard cancer treatments are surgery, radiation,immunotherapy or chemotherapy. To the moment chemotherapy is the most effective to treat the malignant disease. However, the cancer cells develop drug resistance to chemotherapy, has been a significant impediment to treatment so new therapeutic alternatives are required .

• Albendazole is a benzaimidazole derivative that was introduced as an antihelmintic. The mechanism of action of ABZ is related to microtubule inhibition and blocking glucose uptake that causes depletion of glycogen stores. and lowering the formation of ATP in the larval and adult stages of the susceptible parasites. Altogether it leads to immobilization and death of parasite.
• ABZ possesses anti proliferative effects against several tumor cell
• cancer cells are under high oxidative stress because they possess altered antioxidant defenses and some research proves that reactive oxygen species(ROS) induced by anti cancer drugs produce a shift in cellular antioxidant machinery as well as in the mitochondrial membrane potential which induces cell death. ABZ shows increased ROS promotion thereby promoting oxidative stress and this is used as an approach for cancer treatment
• ALBENDAZOLE.