Question

If the wild type DNA sequence reads THE CAT ATE THE BIG RAT, what type of mutation would change the sequence to THE CAT ATT HEB IGR AT?

Answer 1

Ans:- Frameshift mutation will change the sequence.

Frameshift mutation :- A Frameshift mutation ( also called a framing error of reading shift) is a genetic mutation caused by indels ( insertion or deletion) of a number of nucleotides in a DNA sequence that is not divisible by three. Due to the triplet nature of gene expression by codons, the insertion and deletion can change the reading frame, resulting in a completely different translation from the original. For example :- original sequence :- THE CAT ATE THE BIG RAT,

Frameshift sequence :- THE CAT ATT HEB IGR AT.