Problem

Shown below are several amino acid substitutions in the α and β chains of human hemoglobin...

Shown below are several amino acid substitutions in the α and β chains of human hemoglobin:

Hb Type

Normal Amino Acid

Substituted Amino Acid

Hb Toronto

Ala

Asp (α-5)

HbJ Oxford

Gly

Asp (α-15)

Hb Mexico

Gln

Glu (α-54)

Hb Bethesda

Tyr

His (β-145)

Hb Sydney

Val

Ala (β-67)

HbM Saskatoon

His

Tyr (β-63)

Using the code table (Figure), determine how many of them can occur as a result of a single-nucleotide change.

Figure

The coding dictionary. AUG encodes methionine, which initiates most polypeptide chains. All other amino acids except tryptophan, which is encoded only by UGG, are represented by two to six triplets. The triplets UAA, UAG, and UGA are termination signals and do not encode any amino acids.

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