Question

1. , why does a deficiency of estrogen in women lead to osteoporotic change?

Answer 1

So let us discuss this important concept of relation between estrogen and osteoporosis

You might have heard that as soon as womens age the chances of there fractures increase . This apply same to mens but females are more early affected . So

Normally there are 2 type of cells responsible for bone growth and maturation . These are osteoclast and osteoblast cells .

Osteoclasts cells are the cells which help in bone resorption which is necessary for maintaining the calcium level in the body

As osteoclast cells weaken the bones and forms pores . The osteoblast cells are the cells which help in again filling the bone which is lost due to osteoclast cells . This is a normal physiological phenomenon

Now estrogen is a sex hormone produced from ovaries

It is said that estrogen decrease the production of osteoclast cells by promoting apoptosis . And increase the function of osteoblasts cells . So as women age when they are near to menopause there is suddenly deficiency of estrogen occur . Which increase the function of osteoclast cells and hence the bone become porous

That's why post menopausal women are advised to take hormone replacement therapy

Below is a chart which shows the relation of estrogen and bone cells

ESTROGEN 0ςτεύτες OSTEOBLAST S OSTECLASTS deveare apoptocis deveare gncrease a poptosis Qaeod oebcur apoptsis Maintain thuis Leads to decsease Cse) Bone resaotion Jactivation ot Bone emodstlin Bone Ltomation

Hope you find this helpful thankyou ☺️?