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A rare autosomal dominant condition affects the following family pedigree. What is the probability that the unborn child mark

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Answer #1

Mother of the unborn child is Aa for sure. So, her probability will be 1.

Father of the unborn child can be AA or Aa.

The parents of the father are Aa × Aa.

Probability that the father is AA = 1/3

Probability that the father is Aa = 2/3

Case 1 - father is AA

AA × Aa = 1 A_ (all affected)

Probability that the child is affected = 1 × 1/3 × 1 = 1/3

Case 2 - father is Aa

Aa × Aa = 3/4 A_, 1/4 aa

Probability that the child is affected = 1 × 2/3 × 3/4 = 1/2

Final answer -

Probability that the child is affected = if father is AA or if father is Aa = 1/3 + 1/2 = 5/6

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