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in Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila the authors found that ectopic express
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ey gene encode for protein that contain both paired domain and homodomain. The homeobox protein determine the anterior-posterior axis of drosophila. ey gene is similar to pax-6 of mouse and aniridia of human. These genes are invove in development of nervous system and eye during morphogenesis.

Mutation or any other kind of change in expression in this gene results in reduction or complete absence of all eye structure, and because ey is similar in DNA sequences and expression pattern even at the earlier stage of eye development, it is said to have universal effects on cell.

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