Question

What happens if the spliceosome makes a small mistake, such as inserting or deleting a single nucleotide from the final spliced mRNA?

- Can mutations in the DNA destroy a splice site? What is the consequence for the protein if and when this happens?

- Can mutations in the DNA create new splice sites? If so, what is the consequence for the protein?

Answer 1

Question

The spliceosome are the group of proteins which is involved in the removing introns from the pre-mRNA to form mRNA. The spliceosome is highly efficient in its function and produce mRNA that produce correct proteins needed by the cell to perform cellular function. But in case, if due to mistake , spliceosome either insert or delete one nucleotide, it lead to the formation of incorrect mRNA after splicing and that further lead to the formation of incorrect protein in the cell that lead to formation of many abnormal condition in the cell.

Yes, mutation in the DNA could destroy a splice site. This is because DNA is converted into RNA by transcription that futher change into the protein. If this mutation would occur, it would lead to the formation of incorrect protein or immature protein, therefore, it lead to the abnormal condition in the cell.

Yes, mutation in the DNA create new splice sites. If this mutation occur, it would lead to the formation of abnormal or immature protein