Question

3. NF-kB is a transcriptional activator. In its active form, it binds to DNA and helps to activate expression of many genes, including B-interferon. In terms of what you know about enhancers and enhanceosomes, explain why active NF-kB by itself is unable to cause B-interferon to be expressed.

Answer 1

ANSWER: It is described as follows (rate if answer is helpful thanks)

GPCR signalling →PEP-2 pathway Activates PK- IK-B NE-KB exoression (PNK-B activates IK-B kinase] Degerded by - web Quitanghati free and active LPS, IEN, Ik-Inhibitory of Gene Expression _ Kappa-B • NEK Nuclere factor kappe. stress is T, B-cell activation h a Healing Scanned with CamScanner cs Scanned with CamScanner

prillropilu NF-kB is an imp. transcription facter induces gene expression. IK-B is a natural inhibitor en NF-kB and forevents the its translocation into the nucleus. In presence of external stimule like LPs, Proin flamatory O molecules , NE-KB û activateer In the csignalling Ik-B kinases is activated which causes phosphorylation of Ik-B - upen phosphorylation Ik-B undergoes ubiquition mediated degradation, NI NE KB becomes free and translocates inte. the nucleus to induce gene expressen GRER signalling can also activate NF-kB. Pk-c activated in PIP-2 signalling also promotes phosphorylation dependent elegralties quik-BI- pada a stung als Phonbol estar induces NF-kB activation I therefore is used to induce inflamation This is a good example of tve cross talks Note Phorbol Scanned with CamScanner Scanned with CamScanner