Homework Answers
Ans- shortening of chromosomes
Telomerase present at the ends of each chromosome hence, shortening of chromosomes disrupts telomerase function.
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What would be a likely result of a mutation that disrupts telomerase function? Cancer Shortening of...
Cancer Biology 8. Re-expression of telomerase can confer immortality to emerging clones of tumor cells, and...
Cancer Biology
8. Re-expression of telomerase can confer immortality to emerging clones of tumor cells, and was originally viewed as an attractive target for drug discovery. However, which of the following best explains the lack of therapeutic efficacy for telomerase inhibitors? a. Telomerase alone is sufficient for transformation in human cells. b. Telomerase is required for the maintenance of somatic cell populations. c. Too many post-inhibition cell doublings would be required to see anti-tumor efficacy. d. Telomerase has sequence and...
What would be the likely result of activation of telomerase in somatic cells? A) immediate cell...
What would be the likely result of activation of telomerase in somatic cells? A) immediate cell death B) Nothing, as somatic cells already have active telomeres C) Cells capable of continuous division D) premature aging of the cell E) Cells displaying extensive DNA rearrangement and mutation
Which of the following would result from a mutation that disrupts the formation of hemidesmosomes? An...
Which of the following would result from a mutation that disrupts the formation of hemidesmosomes? An increased risk of bacterial infection due to increased basal lamina permeability. Disrupted formation of epithelial sheets due to an absence of desmosomes. Embryonic lethality due to disruption of tight junctions. Decreased epidermal integrity due to disrupted contact with intermediate filaments. Desmosomes connect the _______________ of two cells together. Because they connect this component of the cytoskeleton, desmosomes play a role in resisting _______________ on...
Match the following phenotypes with the mutation that would be the most likely to be its...
Match the following phenotypes with the mutation that would be the most likely to be its cause. The mutant proteins are listed below, followed by the protein domain that is mutated in each case, followed by the amino acid change that is a result of the mutation Try to answer each question by using the following reasoning: if you observe a phenotype, then that could be due to a mutation in protein in which the domain has had an amino...
A point mutation within what functional part of a DNA sequence would be most likely result...
A point mutation within what functional part of a DNA sequence would be most likely result in the production of a protein that differs from the non-mutated form by only a single amino acid? a.Promoter b.5’ or 3’ Untranslated regions c.Exons d.Introns What if the mutation prevented transcription? What if the mutation prevented the mRNA from exiting thenucleus?
2) What is the most likely phenotype of a loss of function mutation in a proto-oncogene?...
2) What is the most likely phenotype of a loss of function mutation in a proto-oncogene? (you may select more than one answer) a) Increased cell division b) decreased cell division c) cancer d) non-disjunction
Q17 Homework – Unanswered What type of physical mutation would most likely occur as a result...
Q17 Homework – Unanswered What type of physical mutation would most likely occur as a result of exposure to Oxygen free-radicals? o A nonsense O B missense 0 C silent O D polymorphism O E frameshift
If a mutation occurs as a result of X-ray exposure, what genetic classification of mutation would...
If a mutation occurs as a result of X-ray exposure, what genetic classification of mutation would most likely occur? A hypomorph B hypermorph C neomorph D antimorph E amorph F frameshift G haploinsufficient
Q14 Homework. Unanswered What type of physical mutation would most likely occur as a result of...
Q14 Homework. Unanswered What type of physical mutation would most likely occur as a result of X-ray exposure? o A nonsense 0 B missense - nonsynomous o C missense - synomous o D silent O E polymorphism O F frameshift
A mutation results in the production of much less DNA ligase than normal. What would be...
A mutation results in the production of much less DNA ligase than normal. What would be a likely consequence? DNA replication would not be able to occur at all. DNA replication would occur, but the leading strand would be composed of many small fragments. DNA replication of both strands would occur slowly because the unwinding of DNA would be impaired. DNA replication would occur, but replication of the lagging strand would take much longer than normal.
Cancer Biology
8. Re-expression of telomerase can confer immortality to emerging clones of tumor cells, and was originally viewed as an attractive target for drug discovery. However, which of the following best explains the lack of therapeutic efficacy for telomerase inhibitors? a. Telomerase alone is sufficient for transformation in human cells. b. Telomerase is required for the maintenance of somatic cell populations. c. Too many post-inhibition cell doublings would be required to see anti-tumor efficacy. d. Telomerase has sequence and...
Match the following phenotypes with the mutation that would be the most likely to be its cause. The mutant proteins are listed below, followed by the protein domain that is mutated in each case, followed by the amino acid change that is a result of the mutation Try to answer each question by using the following reasoning: if you observe a phenotype, then that could be due to a mutation in protein in which the domain has had an amino...
Q17 Homework – Unanswered What type of physical mutation would most likely occur as a result of exposure to Oxygen free-radicals? o A nonsense O B missense 0 C silent O D polymorphism O E frameshift
Q14 Homework. Unanswered What type of physical mutation would most likely occur as a result of X-ray exposure? o A nonsense 0 B missense - nonsynomous o C missense - synomous o D silent O E polymorphism O F frameshift
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