Question

7. From what you understand about enzymes, explain why a change in an amino acid would cause Harry's enzyme to lose its function. 8. In both of Henry's mutations, it is the first nucleotide in the DNA triplet code that has been changed. a. Using the genetic code chart below, create a list of single nucleotide changes in the two affected triplet codes described for Henry's genes that could occur WITHOUT resulting in a change in the amino acid in the enzyme. NOTE: The code chart below contains mRNA codons and the amino acids associated with those codons. Your list should contain DNA triplet codes.

Answer 1

7. The amino acids have receptor sites that corresponds to their shapes. However the amino acid changes , so does the shape. If the protein fits the site luids. It performs different function. 8. (a) Henry was found to carry a mutation ! in gene for enzyme called CYP2C9 This enzyone Contains 1,400 nucleotides. The DNA tripllet code CGT in the coding strand. Heary. was considered as a poor metaliolizers The nucleotide has been changed from an adenine to a cytosine. Each group of there leases in MRNA constitutes a codon the chain of amino acids that form a protein Multiple colons can code for the same amino acid