Question

Which of the following classes of antimicrobial drugs inhibits protein synthesis?

Select ALL correct answers -- there is more than one!

Aminoglycosides

Oxazolidinones

Nitroimidazoles

Chloramphenicol

Pyrazinamides

Fluoroquinolones

Answer 1

Aminoglycosides work by inhibiting bacterial protein synthesis

Oxazolidinones also inhibit the protein synthesis by binding to ribosome

Nitroimidazoles kills bacteria by inhibiting nucleic acid bio synthesis

Chloramphinicol works by inhibiting peptidyl transferase activity hence inhibit protein synthesis.

Pyrazinamides inhibit pyrazinamidase enzyme that converts pyrazinamides to active form pyrazinoic acid

Fluoroquinolones works by inhibiting DNA gyrase and topoisomerase IV and inhibit protein synthesis

So option A,B and D are correct.