A substitution mutation occurs which changes the amino acid sequence of the active site in an...
A substitution mutation occurs which changes the amino acid sequence of the active site in an enzyme. What will happen to substrate binding as a result of this mutation?
A) It will increase
B) It will decrease
C) It will be eliminated
D) It will be unchanged
E) Either B or C
F) It depends upon what amino acid is substituted
My first choice was E, which is incorrect, my second choice is now F.
Homework Answers
When there is a substitution mutation in the amino acid sequence of an enzymes active site, it alters the primary structure of the protein and thus has a cascade effect to its secondary and tertiary structure which in the end alters the active binding site of the protein. However, whether there will be an increase or decrease of substrate binding activity depends upon the amino acid sequence which has been changed. According to me, option F is more appropriate.
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A substitution mutation occurs which changes the amino acid
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