Oxidative energy generation occurs in three stages: 1. glycolysis 2. TCA cycle 3. electron transport chain. Stage 3 is where most ATP is generated. This process is done by multi-enzyme complexes in the mitochondria (Complex I, Complex II, Complex III, Complex IV and Complex V). If a frame-shift mutation occurred in the gene encoding a protein in one of these complex, identify the one that would cause the most harm and the least harm to the function of the electron transport chain. Explain your choice
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Mutation in the complex V will cause the most harm. This complex, also known as ATP synthase, is responsible for ATP synthesis.
The least harm will be caused by mutation of complex IV as it is the last step of electron transport chain. So, less reduction will occur in the synthesis of ATP.
Oxidative energy generation occurs in three stages: 1. glycolysis 2. TCA cycle 3. electron transport chain....
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