What would happen if p53 was localized in the extracellular lipid bilayer of the cell membrane?...
What would happen if p53 was localized in the extracellular lipid bilayer of the cell membrane? How would this alter cellular physiology?
Homework Answers
p53 is an important tumor suppressor
gene. It is referred to as the guardian of the human genome.
It can activate DNA repair proteins when DNA damage is
detected.
It can arrest cell cycle if DNA replication is not proper.
It can initiate apoptosis if the damage is severe and
unrepairable.
It is essential for senescence.
It contains a DNA binding domain and
several trans-activation domains. It is functional inside the
nucleus to regulate the expression of many genes.
If the protein is not localized to the nucleus i.e. if it is
targetted to the cell membrane, it cannot be functional and would
lead to DNA damage and cancerous cell growth
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What would happen if p53 was localized in the extracellular
lipid bilayer of the cell membrane?...
A cell membrane consists of a lipid bilayer, which is a double layer of phospholipids. Each...
A cell membrane consists of a lipid bilayer, which is a double layer of phospholipids. Each phospholipid has a hydrophilic phosphate head and a hydrophobic lipid tail. These phospholipids are not chemically bound to one another, but rather maintain their structure due to the fact that the lipid tails do not like water. They're hydrophobic^2. If they all buddy up, then they can all stay dry. (See figure.) One way to deal with this quantitatively is to realize that there...
CELL BIOLOGY Chapter 10 The function of a lipid bilayer How is the lipid bilayer formed...
CELL BIOLOGY Chapter 10 The function of a lipid bilayer How is the lipid bilayer formed Know the different types of phospholipids and any unique features and locations (if there are any) Know the overall structure of a phospholipid How does a lipid membrane stay fluid? How to lipid move in a membrane? Just as important, know the movement lipids are unable to do in the absence of flipase. Alberts.-.Molecular.Biology.Of.The.Cell.5th.Ed IS THE TEXT
Question 13 Cells and all organelles within a cell are wrapped in a lipid bilayer membrane...
Question 13 Cells and all organelles within a cell are wrapped in a lipid bilayer membrane What is the purpose of the membrane? 1. To facilitate transcription and translation of new proteins 2. To permanently stop the movement of molecules from one area to another 3. To catalyze chemical reactions 4. To compartmentalize chemical reactions
Which of the below molecules would be expected to be membrane permeable and freely pass through a lipid bilayer? Select...
Which of the below molecules would be expected to be membrane
permeable and freely pass through a lipid bilayer?
Select all that apply
Which of the below molecules would be expected to be membrane permeable and freely pass through a lipid bilayer? Select all that apply. O=C=0 Nat NEN K+ * H-C-OH Ο Ι Ι HHHHHH
What molecules enable cells to respond to a specific extracellular signaling molecule? a. Specific receptor carbohydrates...
What molecules enable cells to respond to a specific extracellular signaling molecule? a. Specific receptor carbohydrates localized to the inner plasma membrane surface b. Plasma lipid bilayer c. Ion channels d. Receptors that specifically recognize and bind that particular messenger molecule
If the lipid bilayer in Section B represents the ER membrane, which part of the protein...
If the lipid bilayer in Section B represents the ER membrane, which part of the protein is found INSIDE the ER (in the ER lumen)? A. COOH 26 oligosaccharides transmembrane a helix cause lipid bilayer B. LSH- C. -NH2 SH Figure 10-22. Molecular Biology of the Cell, 4th Edition O The entire protein must be inside the lumen of the ER. O All sections are equally likely to be in the ER lumen. Section B is inside the ER lumen....
Discuss how the amino acid distribution of a protein that is embedded in the lipid bilayer...
Discuss how the amino acid distribution of a protein that is embedded in the lipid bilayer of the cell ( a membrane protein) differs from the amino acid distribution in globular protein.
1Of the permeable of potassium ions decrease, what would happen to the membrane potential? depolarize is...
1Of the permeable of potassium ions decrease, what would happen to the membrane potential? depolarize is this correct? 2/What will happen to the resting membrane potential if you add potassium ions to the extracellular fluid? it will decrease is this correct 3/ What is oxygen used for in cellular respiration? a/to accept carbon from the citric acid cycle, creating C02 b./to accept hydrogen from NADH, refreshing NAD+, creating H20 which one is correct
The following experiment was conducted to test the fluid mosaic theory. The lipid bilayer of a...
The following experiment was conducted to test the fluid mosaic theory. The lipid bilayer of a cell was saturated with fluorescence, so that it appeared green when viewed under a microscope. The cell membrane was then bleached of colour in a single spot, which appeared white against the green of the rest of the cell membrane when viewed under a microscope. If the cell were left for a time, what would you expect to see when the cell is again...
Why would amphipathic molecules in a lipid membrane drive the membrane to self-seal? Why don’t phospholipids...
Why would amphipathic molecules in a lipid membrane drive the membrane to self-seal? Why don’t phospholipids flip flop across a lipid bilayer, from one side to the other?
A cell membrane consists of a lipid bilayer, which is a double layer of phospholipids. Each phospholipid has a hydrophilic phosphate head and a hydrophobic lipid tail. These phospholipids are not chemically bound to one another, but rather maintain their structure due to the fact that the lipid tails do not like water. They're hydrophobic^2. If they all buddy up, then they can all stay dry. (See figure.) One way to deal with this quantitatively is to realize that there...
Question 13 Cells and all organelles within a cell are wrapped in a lipid bilayer membrane What is the purpose of the membrane? 1. To facilitate transcription and translation of new proteins 2. To permanently stop the movement of molecules from one area to another 3. To catalyze chemical reactions 4. To compartmentalize chemical reactions
Which of the below molecules would be expected to be membrane
permeable and freely pass through a lipid bilayer?
Select all that apply
Which of the below molecules would be expected to be membrane permeable and freely pass through a lipid bilayer? Select all that apply. O=C=0 Nat NEN K+ * H-C-OH Ο Ι Ι HHHHHH
If the lipid bilayer in Section B represents the ER membrane, which part of the protein is found INSIDE the ER (in the ER lumen)? A. COOH 26 oligosaccharides transmembrane a helix cause lipid bilayer B. LSH- C. -NH2 SH Figure 10-22. Molecular Biology of the Cell, 4th Edition O The entire protein must be inside the lumen of the ER. O All sections are equally likely to be in the ER lumen. Section B is inside the ER lumen....
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