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1. Define the restriction point (R point). How do mitogens control the restriction point transition?

1. Define the restriction point (R point). How do mitogens control the restriction point transition?

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A restriction point is a typical point in the G1 phase of a cell cycle. This point acts as a control unit and if the cell bypasses this point, it becomes committed to cell cycle. Typically, after the progression through restriction point, there is no need for mitogens. In most of the cases, mitogens trigger the activation of MAPK/ERK pathway which eventually leads to the expression of genes such as fos, jun and myc. The product of these genes activate cyclins and CDK's which allow a cell to progress through restriction point.

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