Question

Which of the following would result in the largest number of amino acids being changed?

Select one:

a. Silent mutation

b. Missense mutation

c. Frameshift

d. Triplet repeat

Answer 1

Silent mutation - does not change an amino acid but in some cases can still have phenotypic effect Eg by speeding up or down protein synthesis or by affecting splicing .

Missense mutation - changes an amino acid to another amino acid .this may or may not affect protein synthesis , depending on whether the change is conservative or non conservative and what the amino acids actually does.

Frame shift mutation - deletion or insertion of number of bases that is not multiple of 3 .usually introduce premature STOP codon in addition to lots of amino acid changes

Triplet repeat - triplet repeat are site of mutation in three human heritable disorder.

So the answer is - C, frame shift.