Question

What is the percent recovery of the product? (weight of product, acetaminophen=0.320g)

EXPERIMENTAL PROCEDURE 1. Use a mortar and pestle to crush one tablet completely to powder. 2. Transfer the powder to a 5 ml. conical viale be sure to thoroughly scrape the residue from the mortar. 3. Add methanol to the 2 mL mark. 4. Cap the vial do not use an o-ring mix with an automatic mixer for 1 minute, and set aside to let the solids settle. 5. Set up a chromatography column as follows (analogous to the drying column you used previously): a. Insert a piece of cotton inside a Pasteur pipette and clamp it. b. Place your micro funnel in the Pasteur pipette. c. Add about 1/4 inch of sand in the Pasteur pipette. d. Add one inch of alumina in the Pasteur pipette. c. Add 1/4 inch of sand in the Pasteur pipette. 6. Place a 10 mL round bottom flask under a Pasteur pipette (as in Figure 11.2). Micro clamp 7. Add 2 mL methanol to the column and allow it to pass through until the level of methanol has dropped to the top of the sand (the sand on the top). Pasteur pipette 8. Then, carefully transfer the supernatant liq- uid from your Tylenol-methanol mixture to the column using a Pasteur pipette (any solid transferred will clog the column and slow down the process). Sand (1/8 inch) - Alumina (1 inch) Sand (1/4 inch) -Cotton 9. Carefully, force the liquid from the column with a pipette bulb (your instructor will demonstrate). 10. Use 1 mL of methanol to rinse the insoluble ingredients in the 5 mL conical vial and add the rinse to the column. Micro clamp 11. Once all of the liquid has been drained from the column, add a boiling chip to the 10 mL round bottom flask containing the acetamino- phen solution and distill all but 1 mL of the methanol by simple distillation. 10 mL Pear-shaped flask 12. Disassemble the distillation setup and re- move the boiling chip with a spatula; if no solid is present scratch the inside of your vial gently with a glass stirring rod to induce crystallization. Figure 11.2. Chromatography column.

Answer 1

Percent recovery means the percentage of ratio between Substance Collected Compared to the amount of substanu were expected to colleet. Here in the Tylenol tablet 500 mg acetaminophen is present so Therefore expected amount of the acetaminophen to be collected of after the experimental prouss in 500mg if no compound is lost. But here the amount of acetaminophen is collected is 0.3208= 320mg

Torte Therefore Percent recovery - Collected product x100 = Expected product = 320 x - Son X 100 = = 64% So percent recovery of the product in 64%